CHS-111
Product Specifications
CAS Number
886755-63-1
Target
Reactive Oxygen Species, Others
Related Pathways
Others, NF-κB, Immunology/Inflammation, Metabolism
Bioactivity
CHS-111 is a benzyl indazole compound that inhibits superoxide anion (O (2) (-) ) generation and reduces fMLP-stimulated PLD activity (IC (50) 3.9±1.2μM) . It inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homology (Rho) A, and reduces the membrane recruitment of RhoA in fMLP-stimulated cells.
Smiles
C(N1C(=C2C(=N1)C=CC=C2)C3=CC=C(CO)C=C3)C4=CC=CC=C4
Molecular Formula
C21H18N2O
Molecular Weight
314.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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