CHMFL-FLT3-122
Product Specifications
CAS Number
1839150-56-9
Target
Apoptosis, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis
Purity
0.9963
Bioactivity
CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia. CHMFL-FLT3-122 significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft model (50 mg/kg) without exhibiting obvious toxicity in vivo.
Smiles
NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(CN(C)C)=O)CCC5)=NC=N1
Molecular Formula
C26H29N7O2
Molecular Weight
471.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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