Ceralasertib formate
Product Specifications
CAS Number
1352280-98-8
Target
Others, ATM/ATR
Related Pathways
Others, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair
Bioactivity
Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.
Smiles
OC=O.C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@](C)(=N)=O
Molecular Formula
C21H26N6O4S
Molecular Weight
458.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
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