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Ceralasertib formate

Product Specifications

CAS Number

1352280-98-8

Target

Others|||ATM/ATR

Related Pathways

Others|||PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair

Bioactivity

Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.

Smiles

OC=O.C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@](C)(=N)=O

Molecular Formula

C21H26N6O4S

Molecular Weight

458.54

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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