CBS-3595
Product Specifications
CAS Number
908380-97-2
Target
PDE, p38 MAPK, Others
Related Pathways
MAPK, Metabolism, Others
Bioactivity
CBS-3595 is a potent and dual Inhibitor of p38α MAPK/PDE-4 with a superior profile regarding its anti-inflammatory effects. CBS-3595 features moderate inhibition of p38α MAPK and PDE-4 in the higher nanomolar range in combination with excellent kinetic properties and low plasma protein binding contributing to the outstanding results of the efficacy experiments performed in animal models and humans. The inhibition of TNFα release was achieved at dose levels and systemic concentrations that were well below levels related to toxicity.
Smiles
CN1C(=C(N=C1S(C)=O)C2=CC=C(F)C=C2)C=3C=C(NC(C)=O)N=CC3
Molecular Formula
C18H17FN4O2S
Molecular Weight
372.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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