C188
Product Specifications
CAS Number
823828-18-8
Target
Others|||Apoptosis|||STAT
Related Pathways
Apoptosis|||Others|||Stem Cells|||JAK/STAT signaling
Bioactivity
C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect against IFN-?-stimulated HepG2 cellular STAT1 phosphorylation.
Smiles
OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c2ccccc2c1O
Molecular Formula
C19H15NO7S2
Molecular Weight
433.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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