BMS-986118
Product Specifications
CAS Number
1610562-74-7
Target
Others, GPCR
Related Pathways
Endocrinology/Hormones, Others, GPCR/G Protein
Bioactivity
BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial agonists elicits insulin secretion only in the presence of elevated blood glucose levels, minimizing the risk of hypoglycemia.
Smiles
C(C(O)=O)[C@@H]1N(N=C(C(F)(F)F)[C@H]1C)C2=CC=C(O[C@H]3[C@H](C)CN(CC3)C=4C=C(OC)N=CC4Cl)C=C2
Molecular Formula
C25H28ClF3N4O4
Molecular Weight
540.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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