BMS-814580
Product Specifications
CAS Number
1197420-11-3
Target
Melanin-concentrating Hormone Receptor (MCHR), GPCR
Related Pathways
Endocrinology/Hormones, GPCR/G Protein
Bioactivity
BMS-814580 is a potent and selective functional antagonist (Kb = 117 nM) of human MCHR1. BMS-814580 exhibits potent binding affinity (Ki = 17 nM) for human MCHR1. BMS-814580 also exhibits potent binding affinities for cynomolgus monkey and rat MCHR1 (Ki of 4.9 and 11.5 nM, respectively) . MCHR1 antagonist demonstrates reduction in feeding and body weight in rats and mice.
Smiles
O=C1C2=C(C=C(S2)C3=CC=C(Cl)C=C3)N=CN1C4=CC(OC)=C(OCC5(O)CC(F)(F)C5)C=C4
Molecular Formula
C24H19ClF2N2O4S
Molecular Weight
504.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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