AZ-PFKFB3-67
Product Specifications
CAS Number
1704741-11-6
Target
Others, Bcl-2 Family, Phosphatase, Glucokinase
Related Pathways
Metabolism, Apoptosis, Others
Purity
0.9979
Bioactivity
AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with an IC50=11nM for PFKFB3, reduces MCL-1, and inhibits angiogenesis by decreasing lactic acid production and ATP levels in endothelial cells (ECs) in tube-forming assays, and has neuroprotective effects.
Smiles
C(#N)C=1C=2C(N(CC=3C(C)=NOC3C)C1)=CC=C(OC4=CC=C(NC(=O)[C@@H]5CCCN5)C=C4)C2
Molecular Formula
C26H25N5O3
Molecular Weight
455.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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