Avadomide HCl
Product Specifications
CAS Number
1398053-45-6
Target
Others|||Molecular Glues|||NF-?B|||Apoptosis|||E1/E2/E3 Enzyme
Related Pathways
Others|||NF-?B|||Ubiquitination|||PROTAC|||Apoptosis
Bioactivity
Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes degradation of Ikaros and Aiolos in diffuse large B-cell lymphoma (DLBCL) and T cells in vitro, in vivo, and in patients, resulting in both cell autonomous as well as immunostimulatory effects.
Smiles
Cl.O=C1NC(=O)C(N2C(=O)C3=C(N=C2C)C=CC=C3N)CC1
Molecular Formula
C14H15ClN4O3
Molecular Weight
322.75
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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