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Avadomide HCl

Product Specifications

CAS Number

1398053-45-6

Target

Others|||Molecular Glues|||NF-?B|||Apoptosis|||E1/E2/E3 Enzyme

Related Pathways

Others|||NF-?B|||Ubiquitination|||PROTAC|||Apoptosis

Bioactivity

Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes degradation of Ikaros and Aiolos in diffuse large B-cell lymphoma (DLBCL) and T cells in vitro, in vivo, and in patients, resulting in both cell autonomous as well as immunostimulatory effects.

Smiles

Cl.O=C1NC(=O)C(N2C(=O)C3=C(N=C2C)C=CC=C3N)CC1

Molecular Formula

C14H15ClN4O3

Molecular Weight

322.75

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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