AR-H067637
Product Specifications
CAS Number
433937-74-7
Target
Others, Thrombin
Related Pathways
Proteases/Proteasome, Others
Bioactivity
AR-H067637 is a rapid-binding, reversible and potent (inhibition constant K (i) = 2-4 nM), competitive inhibitor of thrombin, as well as of thrombin bound to fibrin (clot-bound thrombin) or to thrombomodulin. The total amount of free thrombin generated in platelet-poor clotting plasma was inhibited concentration-dependently by AR-H067637, with a concentration giving half maximal inhibition (IC (50) ) of 0.6 microM. AR-H067637 also inhibited thrombin-induced platelet activation (by glycoprotein IIb/IIIa exposure, IC (50) 8.4 nM) and aggregation (IC (50) 0.9 nM) .
Smiles
C([C@H](O)C1=CC(OC(F)F)=CC(Cl)=C1)(=O)N2[C@H](C(NCC3=CC=C(C(=N)N)C=C3)=O)CC2
Molecular Formula
C21H21ClF2N4O4
Molecular Weight
466.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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