AM-0687
Product Specifications
CAS Number
1259522-94-5
Target
Others, PI3K
Related Pathways
Others, PI3K/Akt/mTOR signaling
Bioactivity
AM-0687 is a potent and selective PI3Kδ inhibitor. AM-0687 has Cellular potency: pAKT IC50 = 0.7 nM; HWB, u (pAKT) IC 50 = 4.6 nM. Rat KLH: IgG ED50 -= 0.026 mg/kg; IgM ED50 = 0.016 mg/kg. Rat PK Clu = 2.3 L/hr/kg.
Smiles
C(NC)(=O)C1=C(C([C@@H](NC=2C(C#N)=C(N)N=CN2)C)=NC3=C1C=C(F)C=C3)C4=CC=CC=N4
Molecular Formula
C23H19FN8O
Molecular Weight
442.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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