AGI-026
Product Specifications
CAS Number
1446501-77-4
Target
Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolism
Purity
0.9986
Bioactivity
AGI-026 (AGI-12026) is a novel and potent dual inhibitor of the mutant isocitrate dehydrogenase mIDH1/2 with the advantages of oral administration and penetration of the blood-brain barrier, with a drug concentration to plasma concentration ratio (brain/plasma ratio) of 1.5 in brain tissue, and the ability to reduce the accumulation of the carcinogenic metabolite d-2-hydroxyglutarate (2-HG), which is used in the study of mIDH gliomas.
Smiles
FC(F)(F)C1=NC(=CC=C1)C=2N=C(N=C(N2)NC(C)C)NC=3C=CN=C(C3)C(F)(F)F
Molecular Formula
C18H15F6N7
Molecular Weight
443.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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