AG311
Product Specifications
CAS Number
1126602-42-3
Target
Others, Necroptosis
Related Pathways
Others, Apoptosis
Bioactivity
AG311 is an inhibitor of complex I and hypoxia-induced HIF-1α stabilization. In vitro, AG311 induces rapid necrosis in numerous cancer cell lines. Within minutes, exposure to AG311 also results in mitochondrial depolarization, superoxide production, and increased intracellular calcium levels.
Smiles
S(C1=C2C=3C(NC2=CC=C1)=NC(N)=NC3N)C4=CC=C(C)C=C4
Molecular Formula
C17H15N5S
Molecular Weight
321.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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