A 80b
Product Specifications
CAS Number
135561-94-3
Target
Calcium Channel, Others
Related Pathways
Metabolism, Others, Membrane transporter/Ion channel
Bioactivity
A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca (2+) -induced contraction. Hypotensive and antihypertensive effect of A-80b possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.
Smiles
N(NC)=C1C2=C(C(=NN1)N3N=C(C)C=C3C)NC=4C2=CC=CC4
Molecular Formula
C16H17N7
Molecular Weight
307.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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