A 80915A
Product Specifications
CAS Number
127875-60-9
Target
Others, Proton pump, ATPase
Related Pathways
Others, Membrane transporter/Ion channel
Bioactivity
A 80915A is A semi-naphthoquinone antibiotic from Streptomyces aculeolatus. It is a potent inhibitor of gastric (H (+) -K+) -ATPase. Inhibition by A80915A is dependent on the conformation of gastric (H (+) -K+) -ATPase, potassium slows the rate of inhibition by converting the enzyme to a conformation where the drug binding site is not as accessible.
Smiles
Cc1c(O)cc2C(=O)C3(CC4C(=C)CCC(Cl)C4(C)C)OC(C)(C)C(Cl)CC3(Cl)C(=O)c2c1O
Molecular Formula
C26H31Cl3O5
Molecular Weight
529.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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