LGK974
Product Specifications
CAS Number
1243244-14-5
Target
Porcupine
Related Pathways
Stem Cells
Purity
>99.99%
Bioactivity
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck.
Smiles
Cc1cc(ccn1)-c1ncc(CC(=O)Nc2ccc(cn2)-c2cnccn2)cc1C
Molecular Formula
C23H20N6O
Molecular Weight
396.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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