Flavopiridol hydrochloride
Product Specifications
CAS Number
131740-09-5
Target
HIV Protease, Autophagy, CDK
Related Pathways
Proteases/Proteasome, Microbiology/Virology, Autophagy, Cell Cycle/Checkpoint
Purity
0.9988
Bioactivity
Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.
Smiles
Cl.CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Molecular Formula
C21H21Cl2NO5
Molecular Weight
438.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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