GSK2606414
Product Specifications
CAS Number
1337531-36-8
Target
PERK, Autophagy, Apoptosis
Related Pathways
Apoptosis, Autophagy
Purity
>99.99%
Bioactivity
GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase (PERK) inhibitor with IC50 of 0.4 nM. GSK2606414 inhibits PERK activation in cells and suppresses the growth of human tumor xenografts in mice.
Smiles
NC1=C2C(=CN(C)C2=NC=N1)C=3C=C4C(=CC3)N(C(CC5=CC(C(F)(F)F)=CC=C5)=O)CC4
Molecular Formula
C24H20F3N5O
Molecular Weight
451.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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