GSK2606414

Product Specifications

CAS Number

1337531-36-8

Target

PERK|||Autophagy|||Apoptosis

Related Pathways

Apoptosis|||Autophagy

Purity

>99.99%

Bioactivity

GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase (PERK) inhibitor with IC50 of 0.4 nM. GSK2606414 inhibits PERK activation in cells and suppresses the growth of human tumor xenografts in mice.

Smiles

NC1=C2C(=CN(C)C2=NC=N1)C=3C=C4C(=CC3)N(C(CC5=CC(C(F)(F)F)=CC=C5)=O)CC4

Molecular Formula

C24H20F3N5O

Molecular Weight

451.44

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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