Lumacaftor
Product Specifications
CAS Number
936727-05-8
Target
Autophagy, CFTR
Related Pathways
Membrane transporter/Ion channel, Autophagy
Purity
0.9972
Bioactivity
Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM) .
Smiles
Cc1ccc(NC(=O)C2(CC2)c2ccc3OC(F)(F)Oc3c2)nc1-c1cccc(c1)C(O)=O
Molecular Formula
C24H18F2N2O5
Molecular Weight
452.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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