IDO5L
IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM.
Product Specifications
CAS Number
914471-09-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IDO5L.html
Purity
99.89
Solubility
DMSO : ≥ 52 mg/mL
Smiles
ON/C(C1=NON=C1N)=N/C2=CC=C(F)C(Cl)=C2
Molecular Formula
C9H7ClFN5O2
Molecular Weight
271.64
Precautions
H302, H315, H319, H335
References & Citations
[1]Yue EW, et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J Med Chem. 2009 Dec 10;52 (23) :7364-7.|[2]Huang X, et al. Synthesis of [ (18) F] 4-amino-N- (3-chloro-4-fluorophenyl) -N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide (IDO5L) : a novel potential PET probe for imaging of IDO1 expression. J Labelled Comp Radiopharm. 2015 Apr;58 (4) :156-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDO
Available Sizes
Frequently Asked Questions
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