IMM-01
Product Specifications
CAS Number
218795-74-5
Target
Apoptosis, Ras, GTPase
Related Pathways
GPCR/G Protein, Apoptosis, MAPK
Purity
0.9887
Bioactivity
IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia) -related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].
Smiles
CC(C)(C)NC(=S)N\N=C\C1=C(O)C=C(O)C=C1
Molecular Formula
C12H17N3O2S
Molecular Weight
267.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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