Ici 216140

ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50: 2 nM in vitro) . At 2 mg/kg, it can decrease bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been proved to attenuate bombesin-stimulated increases in blood pressure in rats.

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