Ici 216140
Product Specifications
CAS Number
124001-41-8
Target
Others, Bombesin Receptor
Related Pathways
Others, GPCR/G Protein
Bioactivity
ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50: 2 nM in vitro) . At 2 mg/kg, it can decrease bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been proved to attenuate bombesin-stimulated increases in blood pressure in rats.
Smiles
C([C@H](NC([C@H](CC1=CN=CN1)NC(C(C)C)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(NC)=O)CC(C)C)=O)=O)C)=O)[C@H](C)C)=O)C)=O)C=3C=4C(NC3)=CC=CC4
Molecular Formula
C45H65N13O8
Molecular Weight
916.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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