Aleplasinin
Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC50=655 nM) . Aleplastinin activates the tissue type plasminogen activator (tPA) /fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-β (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease[1][2].
Product Specifications
CAS Number
481629-87-2
Product Name Alternative
PAZ-417
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Amyloid-β; PAI-1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aleplasinin.html
Purity
99.59
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)C(C1=CN(CC2=CC=C(C(C)(C)C)C=C2)C3=C1C=C(C4=CC=CC(C)=C4)C=C3)=O
Molecular Formula
C28H27NO3
Molecular Weight
425.52
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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