Filanesib TFA
Product Specifications
CAS Number
1781834-99-8
Target
Kinesin, Others
Related Pathways
Others, Cytoskeletal Signaling
Bioactivity
Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing.
Smiles
C(C(O)=O)(F)(F)F.C(CCN)[C@@]1(N(C(N(OC)C)=O)N=C(S1)C2=C(F)C=CC(F)=C2)C3=CC=CC=C3
Molecular Formula
C22H23F5N4O4S
Molecular Weight
534.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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