Ivabradine hydrochloride
Product Specifications
CAS Number
148849-67-6
Target
HCN Channel, Adrenergic Receptor
Related Pathways
Neuroscience, GPCR/G Protein, Membrane transporter/Ion channel
Purity
0.9973
Bioactivity
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM) . Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.
Smiles
N1(C(=O)Cc2c(CC1)cc(c(c2)OC)OC)CCCN(C)C[C@@H]1c2c(cc(c(c2)OC)OC)C1.Cl
Molecular Formula
C27H37ClN2O5
Molecular Weight
505.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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