Ivabradine hydrochloride
Product Specifications
CAS Number
148849-67-6
Target
HCN Channel, Adrenergic Receptor
Related Pathways
Neuroscience, GPCR/G Protein, Membrane transporter/Ion channel
Purity
0.9973
Bioactivity
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM) . Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.
Smiles
N1(C(=O)Cc2c(CC1)cc(c(c2)OC)OC)CCCN(C)C[C@@H]1c2c(cc(c(c2)OC)OC)C1.Cl
Molecular Formula
C27H37ClN2O5
Molecular Weight
505.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNCB0800-500 1x 500 µL
Cytokeratin 19 (KRT19/800), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![Phospholipase A2 Recombinant Rabbit Monoclonal Antibody [JE41-02]](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea810a6/imageurl/ha721565.webp)
HA721565 100 µL
Phospholipase A2 Recombinant Rabbit Monoclonal Antibody [JE41-02]
Sign In for Pricing
View Details 
BNC941736-500 1x 500 µL
Glycophorin A / CD235a (Erythrocyte Marker) (N/A), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 