2-Amino-6-bromopyridine

2-Amino-6-bromopyridine is an intermediate. 2-Amino-6-bromopyridine is also a PqsR ligand with a Kd value of 6.8 μM in SPR assay. 2-Amino-6-bromopyridine shows weak antagonistic activity. 2-Amino-6-bromopyridine can be used in the synthesis of JAK2 inhibitors, MSK1 inhibitors, and in the research of Pseudomonas aeruginosa infection[1][2][3][4].

Product Specifications

CAS Number

[19798-81-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial; Drug Intermediate

Type

Reference compound

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2-amino-6-bromopyridine.html

Purity

99.97

Solubility

DMSO : ≥ 200 mg/mL

Smiles

NC1=NC(Br)=CC=C1

Molecular Formula

C5H5BrN2

Molecular Weight

173.01

Precautions

H315, H319, H335

References & Citations

[1]Michael Zender, et al. Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence. J Med Chem. 2013 Sep 12;56 (17) :6761-74. |[2]Siu M, et al. 2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors. Bioorg Med Chem Lett. 2013 Sep 1;23 (17) :5014-21. |[3]Wang J, et al. Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents. Sci Rep. 2017 Mar 23;7:45145.|[4]Bollenbach M, et al. Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model. Molecules. 2021 Jan 13;26 (2) :391.