(R) - (-) -Gossypol

(R) - (-) -Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

Product Specifications

CAS Number

[90141-22-3]

Product Name Alternative

AT-101; R- (-) -gossypol acetic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Bcl-2 Family

Type

Natural Products

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AT-101.html

Purity

98.82

Solubility

DMSO : ≥ 200 mg/mL

Smiles

OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O

Molecular Formula

C30H30O8

Molecular Weight

518.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-) -Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10 (22) :7757-63.|[2]Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7 (9) :1418-26.