(R) - (-) -Gossypol
(R) - (-) -Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
Product Specifications
CAS Number
90141-22-3
Product Name Alternative
AT-101; R- (-) -gossypol acetic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Bcl-2 Family
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AT-101.html
Purity
98.82
Solubility
DMSO : ≥ 200 mg/mL
Smiles
OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O
Molecular Formula
C30H30O8
Molecular Weight
518.55
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
Phase 2
Isoform
Bcl-2; Bcl-xL; Mcl-1
Citation 01
Cancer Lett. 2019 Oct 1:461:31-43.|Nat Commun. 2023 Jun 10;14 (1) :3445.
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