DC_AC50

DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones) . Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance[1].

Product Specifications

CAS Number

[497061-48-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dc-ac50.html

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=C(SC2=C1C=C3CCCC3=N2)C(NC4=C(Br)C=C(C=C4F)F)=O

Molecular Formula

C17H12BrF2N3OS

Molecular Weight

424.26

Precautions

H315, H319, H335

References & Citations

[1]Jordon M Inkol, et al. Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy. Vet Comp Oncol. 2020 Dec;18 (4) :559-569.|[2]Jing Wang, et al. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7 (12) :968-79.