DC_AC50
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones) . Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance[1].
Product Specifications
CAS Number
[497061-48-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dc-ac50.html
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=C(SC2=C1C=C3CCCC3=N2)C(NC4=C(Br)C=C(C=C4F)F)=O
Molecular Formula
C17H12BrF2N3OS
Molecular Weight
424.26
Precautions
H315, H319, H335
References & Citations
[1]Jordon M Inkol, et al. Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy. Vet Comp Oncol. 2020 Dec;18 (4) :559-569.|[2]Jing Wang, et al. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7 (12) :968-79.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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