CH5447240
Product Specifications
CAS Number
1253919-92-4
Target
Others, Thyroid hormone receptor (THR)
Related Pathways
Endocrinology/Hormones, Others
Bioactivity
CH5447240 is an effective Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for the treatment of Hypoparathyroidism. CH5447240 showed a potent in vitro hPTHR1 agonist effect (EC20: 3.0 nM; EC50: 12 nM) . It showed 55% oral bioavailability and a significantly elevated serum calcium level in hypocalcemic model rats.
Smiles
O=C1C2(NC(=N1)[C@H]3CC[C@H](C)CC3)CCN(S(CCC4=C(C)C=C(N(C(N)=O)C)C=C4C)(=O)=O)CC2
Molecular Formula
C26H39N5O4S
Molecular Weight
517.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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