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Linifanib

Product Specifications

CAS Number

796967-16-3

Target

PDGFR, c-Kit, VEGFR, FLT, Apoptosis, CSF-1R, Autophagy, c-Fms

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis, Autophagy, Apoptosis

Purity

0.9929

Bioactivity

Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM) . Linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3) .

Smiles

Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1

Molecular Formula

C21H18FN5O

Molecular Weight

375.4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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