Plinabulin
Product Specifications
CAS Number
714272-27-2
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Purity
>99.99%
Bioactivity
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells (IC50: 9.8-18 nM) . Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division.
Smiles
CC(C)(C)c1[nH]cnc1C=c1[nH]c(=O)c(=Cc2ccccc2)[nH]c1=O
Molecular Formula
C19H20N4O2
Molecular Weight
336.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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