(Z) -Semaxinib
Product Specifications
CAS Number
194413-58-6
Target
VEGFR, c-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9999
Bioactivity
(Z) -Semaxinib (SU5416) is a potent and selective VEGFR (Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. (Z) -Semaxinib is a quinolone derivative with potential antineoplastic activity.
Smiles
C(=C\1/C=2C(NC1=O)=CC=CC2)\C=3NC(C)=CC3C
Molecular Formula
C15H14N2O
Molecular Weight
238.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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