PD 151746
Product Specifications
CAS Number
179461-52-0
Target
Proteasome, Cysteine Protease
Related Pathways
Ubiquitination, Proteases/Proteasome
Purity
0.9863
Bioactivity
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM) . Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
Smiles
OC(=O)C(S)=Cc1c[nH]c2ccc(F)cc12
Molecular Formula
C11H8FNO2S
Molecular Weight
237.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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