TSI-01
Product Specifications
CAS Number
704878-75-1
Target
Others, PAFR
Related Pathways
Others, GPCR/G Protein
Purity
0.9987
Bioactivity
TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 μM and 3.02 μM for human LPCAT2 and LPCAT1, respectively) . At 60 μM, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.
Smiles
O=C(OC(C)C)C1=CC=C(C=C1)N2C(=O)C(Cl)=C(Cl)C2=O
Molecular Formula
C14H11Cl2NO4
Molecular Weight
328.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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