SP-100030
Product Specifications
CAS Number
154563-54-9
Target
NF-κB
Related Pathways
NF-κB
Purity
0.9979
Bioactivity
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the severity of murine collagen-induced arthritis (CIA) .
Smiles
C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(=O)C=2C(C(F)(F)F)=NC(Cl)=NC2
Molecular Formula
C14H5ClF9N3O
Molecular Weight
437.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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