SKA-111
Product Specifications
CAS Number
1369170-24-0
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.999
Bioactivity
SKA-111 is a selective calcium-activated potassium phannel (potassium phannel) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases.
Smiles
NC1=NC=2C=3C(C(C)=CC2S1)=CC=CC3
Molecular Formula
C12H10N2S
Molecular Weight
214.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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