Hh-Ag1.5
Product Specifications
CAS Number
612542-14-0
Target
Hedgehog/Smoothened
Related Pathways
Stem Cells, GPCR/G Protein
Purity
0.9987
Bioactivity
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons.
Smiles
CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2c(F)ccc(F)c2c1Cl
Molecular Formula
C28H26ClF2N3OS
Molecular Weight
526.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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