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Rubone

Product Specifications

CAS Number

73694-15-2

Target

MicroRNA

Related Pathways

Chromatin/Epigenetic

Purity

0.9892

Bioactivity

Rubone (2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone), a natural product and a modulator of miR-34a (microRNA-34), upregulates miR-34a expression in a p53-dependent manner, which in turn downregulates the expression of downstream targets Bcl-2, cyclin-D1, CDK6, SIRT1, and FOXP1, thereby inhibiting tumor growth and reversal of hepatocellular carcinoma (HCC) and chemoresistance in prostate cancer.

Smiles

C(=C/C(=O)C1=C(OC)C=C(OC)C=C1O)\C2=C(OC)C=C(OC)C(OC)=C2

Molecular Formula

C20H22O7

Molecular Weight

374.38

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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