Rubone
Product Specifications
CAS Number
73694-15-2
Target
MicroRNA
Related Pathways
Chromatin/Epigenetic
Purity
0.9892
Bioactivity
Rubone (2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone), a natural product and a modulator of miR-34a (microRNA-34), upregulates miR-34a expression in a p53-dependent manner, which in turn downregulates the expression of downstream targets Bcl-2, cyclin-D1, CDK6, SIRT1, and FOXP1, thereby inhibiting tumor growth and reversal of hepatocellular carcinoma (HCC) and chemoresistance in prostate cancer.
Smiles
C(=C/C(=O)C1=C(OC)C=C(OC)C=C1O)\C2=C(OC)C=C(OC)C(OC)=C2
Molecular Formula
C20H22O7
Molecular Weight
374.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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