Poloppin
Product Specifications
CAS Number
683808-78-8
Target
Kras, Others, Autophagy, PLK, Ras
Related Pathways
Cell Cycle/Checkpoint, Autophagy, Others, MAPK
Bioactivity
Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells.
Smiles
OC(=O)CCC1=CC=C(N1C1=C(C=CC=C1)C(F)(F)F)C1=CC=C(Br)C=C1
Molecular Formula
C20H15BrF3NO2
Molecular Weight
438.24
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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