Rilmenidine (phosphate)
Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3].
Product Specifications
CAS Number
85409-38-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rilmenidine-phosphate.html
Purity
99.48
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 83.33 mg/mL (ultrasonic)
Smiles
O=P(O)(O)O.C1(NC(C2CC2)C3CC3)=NCCO1
Molecular Formula
C10H19N2O5P
Molecular Weight
278.24
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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PPP2R5D (Serine/Threonine-Protein Phosphatase 2A 65kD Regulatory Subunit A delta Isoform, PP2A B Subunit Isoform B'-delta, PP2A B Subunit Isoform B56-delta, PP2A B Subunit Isoform PR61-delta, PP2A B Subunit Isoform R5-delta, MGC2134, MGC8949)
Canalicular multispecific organic anion transporter 2
Canalicular multispecific organic anion transporter 2
Canalicular multispecific organic anion transporter 2