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IRAK4-IN-16

Product Specifications

CAS Number

1812188-83-2

Target

IRAK, Others

Related Pathways

Immunology/Inflammation, Others, NF-κB

Bioactivity

IRAK4-IN-16 (compound 4) is a potent inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with an IC50 of 2.5 nM. It exhibits cytotoxicity against OCI-LY10, TMD8, Ramos, and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 μM, respectively [1].

Smiles

C(NC=1C(C(F)F)=NN(C)C1)(=O)C2=C3N(N=C2)C=CC(N[C@@H]4CCCNC4)=N3

Molecular Formula

C17H20F2N8O

Molecular Weight

390.39

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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