Inflachromene
Product Specifications
CAS Number
908568-01-4
Target
P38 MAPK, NF-κB, ERK, JNK, Others
Related Pathways
MAPK, NF-κB, Others
Purity
0.9988
Bioactivity
Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial proliferation through the HMGB1/2-regulated TLR4-NF-κB pathway, and inhibits autophagy by regulating Beclin 1 activity. Inflachromene can be used to study epilepsy.
Smiles
CC1(C)Oc2cc(O)ccc2C2C1=CCn1n2c(=O)n(-c2ccccc2)c1=O
Molecular Formula
C21H19N3O4
Molecular Weight
377.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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