HTH-01-091
Product Specifications
CAS Number
2000209-42-5
Target
MTOR, DYRK, Serine/threonin kinase, GSK-3, Pim, MELK, CDK, RIP kinase
Related Pathways
Cell Cycle/Checkpoint, JAK/STAT signaling, Chromatin/Epigenetic, Apoptosis, Metabolism, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, NF-κB, Stem Cells
Purity
0.9882
Bioactivity
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM) that also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2. It can be used to study breast cancer.
Smiles
O=C1N(C2=C3C(=NC=C2CN1)C=CC(=C3)C4=CC(Cl)=C(O)C(Cl)=C4)[C@@H]5CC[C@@H](CN(C)C)CC5
Molecular Formula
C26H28Cl2N4O2
Molecular Weight
499.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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